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Image Search Results
Journal: Journal of immunology (Baltimore, Md. : 1950)
Article Title: Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space.
doi: 10.4049/jimmunol.173.2.1307
Figure Lengend Snippet: FIGURE 4. Effect of adhesion-blocking Abs or transient neutropenia on PLY-induced neutrophilic alveolitis and lung permeability increase in in- tact mice. A, Mice were either left untreated (0-h time point) or treated with PLY in the absence of function-blocking Abs (40 ng/mouse; f) or received i.v. injections of function-blocking anti-CD18 Abs () or anti-CD18 plus anti-CD49d Abs (v) or were pretreated with anti-Gr-1 to induce neutro- penia (z) followed by intratracheal application of PLY (40 ng/mouse). Mice were sacrificed at the indicated time points and subjected to BAL for determination of BAL fluid leukocyte differentials. B, Mice were either treated with PLY alone (f in B) or were pretreated with anti-CD18 and anti-CD49d Abs (v in B) or were made transiently neutropenic (z in B) followed by PLY application. One hour before sacrifice, mice then re- ceived FITC-labeled albumin i.v. to determine lung vascular leakage. , p 0.01 vs PLY-alone treatment. Values are given as mean SD of five experiments. AU, Arbitrary unit.
Article Snippet:
Techniques: Blocking Assay, Permeability, Labeling